Synthesis of N, N-diethyl-2-Hydroxybenzamide Using Methyl Salicylate from Gandapura Oil
Abstract
The synthesis of N,N-diethyl-2-hydroxybenzamide used methyl salicylate from gandapura oil was conducted. This study aims to find out the synthesis process of N,N-diethyl-2-hydroxybenzamide from methyl salicylate. Methyl salicylate from gandapura oil was mixed with 40% diethylamine solution in diethyl eter and 1% NaOH solution in methanol. The mixture was stirred at 0°C for 1 hour and continued for 24 hours at room temperature. Compound synthesized was separated and determined physical properties include color, shape, odor and melting point, and was identified by FT-IR spectrophotometer and Gas Chromatography-Mass Spectrometer (GC-MS). The results of identification by FT-IR spectrophotometer showed absorption at 1631.67 cm-1 which is the C = O stretching vibrations of amide. The identification results obtained by GC-MS 6 peak. Peak with a retention time of 26.948 minutes with the fragmentation pattern is thought to be the target compound (N, N-diethyl-2-hidroksibenzamida). Identification results from GC-MS obtained 6 peak, and peaks with the retention time of 14.363 minutes showed the presence of methylsalicylate compounds, whereas the peak with a retention time of 26.948 minutes is suspected to be the synthesized compounds (N,N-diethyl-2-hydroxybenzamide). Target compounds synthesized gained by 0.21% in the form of brown solid matter with a melting point of 106-112oC.
Keywords
Full Text:
PDFReferences
Makmun (2005), Penyulingan dan Analisis Beberapa Jenis Minyak Gandapura, Balai Penelitian Tanaman dan Obat, no.2, vol. 16.
Hernani (2004), Gandapura : Pengolahan, Fitokimia, Minyak Atsiri dan Daya Herbisida, Balai Penelitian dan Pengembangan Pascapanen Pertanian, 15.
Supardi and Tri B. (2006), Perancangan Pabrik Asam Salisilat dari Phenol, Jurusan Teknik Kimia, FTI Institut Teknik Nasional, Bandung.
Ilham (2009), Keracunan Aspirin, http://healthreference-ilham.blogspotcom/ 2008/11/keracunan-aspirin.html, diakses tanggal 4 Oktober 2011.
Rahmawati (2008), Pengaruh Kombinasi Basis Polietilenglikol 1000 dan Polietilenglikol 4000 Terhadap Sifat Fisik dan Pelepasan Salisilamida Pada Sediaan Supositoria, Skripsi Fakultas Farmasi, Universitas Muhammadiyah Surakarta, Surakarta.
Vyvyan, J. (1998), Nucleophilic Substitution, Departement of Organic Chemistry, University Florida.
Fessenden, R.J., and Fessenden, J.S., (1989), Kimia Organik, Jilid 2, edisi ketiga, diterjemahkan oleh: A.H. Pudjaatmaka, Erlangga, Surabaya.
Anonim (2010), N,N-dethylsalicylamide, http://www.chemicalbook.com, accessed at April 8th, 2012.
DOI: http://dx.doi.org/10.21776/ub.natural-b.2013.002.01.14
Refbacks
- There are currently no refbacks.