Radiation Effects on Decreased Estrogen with Isoflavone Consumption to Prevent Early Menopause in Radiation Therapy
Abstract
Radiation effect is one of which is the reduction in estrogen. Gamma rays are ionizing radiation that can lead to cell damage due to free radicals produced when the radiation interacts with cells. The level of cell damage can be minimized by antioxidants. Antioxidants used is the isoflavones of soy milk, so it can be know the effects of radiation on the decline in estrogen that accompanied the consumption of isoflavones to prevent early menopause in radiation therapy.
Radiation exposure are given fractionally. The dose was 1,5 Gy in once exposure and given every 3 days up to a maximum dose of the treatment groups. Consumption of soy milk to the mice done orally. Blood was drawn and serum was made. Serum estrogen levels will be tested by using ELISA.
The results showed that the ovarium disfunction and stress experienced by mice (Mus musculus) caused by radiation exposure. Maximum results in the consumption of isoflavones on estrogen levels the subject to radiation exposure is 44 mg/day and 131 mg/day of soy milk. This isoflavone dose increase in estrogen levels maximumly. The increase was the response given by the body's immune system of mice due to start reacting and isoflavones are phytoestrogens.
Keywords
Full Text:
PDFReferences
Alatas, Z. (2006), Efek pewarisan akibat radiasi pengion, Buletin ALARA, 8(2).
Allen, R. G., M. Tressini (2000), Oxidative stress and gene regulation, Free Radical Biol Med, 28, 463-499.
Anwar, R. (2005), Sintesis, fungsi dan interpretasi pemeriksaan hormon reproduksi, Bagian obstetri dan ginekologi, Fakultas Kedokteran UNPAD, Bandung.
Astuti, S. (2008), Isoflavon kedelai dan potensinya sebagai penangkap radikal bebas, Teknologi Industri dan Hasil Pertanian, 13.
Astuti, S. (2009), Pengaruh pemberian tepung kedelai kaya isoflavon seng dan vitamin E terhadap fertilitas tikus jantan sebagai hewan model, Sekolah Pascasarjana Istitusi Pertanian Bogor Bogor.
Ayuningtyas, A. (2009), Makalah kimia dasar, isoflavon dalam kedelai memberi banyak manfaat bagi tubuh, Jurusan Teknologi Pangan, Fakultas Teknologi Industri Pertanian, Universitas Padjajaran, Bandung.
BATAN (2000), Materi diklat petugas proteksi radiasi bidang radiodiagnostik, Jakarta.
Halliwell, B. (1991), Reactive Oxygen species in living system : Source, biochemistry and role in human diseases, Am.J.Med: suppl. 3C, paper 3C-14S.
Hernawati (2013), Perbaikan kinerja reproduksi akibat pemberian isoflavon dari tanaman kedelai, Jurusan Pendidikan Biologi, FPMIPA Universitas Pendidikan Indonesia.
Kreshnamurti, I (2012), Radioterapi pada kanker serviks, Departemen Obstetri Dan Ginekologi Fakultas Kedokteran Universitas Sriwijaya Palembang.
Maulida, F. (2010), Efek ekstrak daun krokot (portulaca oleracea l.) terhadap kadar alanin transaminase (ALT) tikus putih (rattus norvegicus) yang diberi minyak goreng deep frying, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta.
Meirow, D. (2001), The effects of radiotherapy and chemotherapy on female reproduction, Human reproduction update, 7 535-543.
Miladiyah, I. (2004), Isoflavon kedelai sebagai alternatif terapi sulih hormon (TSH), Kedokteran Yarsi 12: 94-99.
Miller (1998), Effect of dietary Patterns on measures of lipid peroxidation: results from a randomized clinical trial, Circulation, 98: 2390-2395.
Murray, R. K., D. K. Granner, P. A. Mayes, and V. W. Rodwell (2003), Harper’s Biochemistry, 6th Edition, Lange Medical, California.
Pramono (2012), Nutrisi massa menopause mencegah osteoporosis, DOI: www.rsulin.com. diakses tanggal 10 Juli 2012.
Sies, H. (1991) Oxidative stress : from basic research to clinical applications, Am.J.Med. 91: suppl. 3C, paper 3C-31S.
Suryohudoyo, P. (1993), Oksidan, antioksidan dan radikal bebas, Universitas Airlangga Press, Surabaya.
Susanti, E.M. (2013), Efek berbagai jenis pakan kedelai (Glycine max L. Merrill) terhadap produk hormon estrogen pada tikus Sprague dawley betina, Departemen Biokimia, FMIPA, Institut Pertanian Bogor.
Winarsi, H., D. Muchtadi, F.R. Zakaria and B. Purwantoro (2004), Respon hormonal-imunitas wanita premenopause yang diintervensi minuman fungsional berbasis susu skim yang disuplementasi dengan 100 mg isoflavon kedelai dan 8 mg Zn-sulfat (SUSU MENO), Teknol. dan Industri Pangan, XV: 28-34.
Winarti, S (2010), Makanan fungsional, Graha ilmu, Yogyakarta.
DOI: http://dx.doi.org/10.21776/ub.natural-b.2013.002.02.2
Refbacks
- There are currently no refbacks.