Preparation of Chitosan-Fe3O4 Nanoparticles by In-situ Co-Precipitation Using Tripolyphosphate / Citrate as Crosslinker and Characterization Using XRD
Abstract
Chitosan-Fe3O4 nanoparticles have been synthesized in a one pot reaction by combine TPP: citrate as crosslinker. The method was in-situ co-precipitation of iron salts in the presence of chitosan and crosslinker. The aim of this study was to determine the effect of preparation process towards chitosan-Fe3O4 nanoparticles characteristics which was prepared on several preparation condition: chitosan:Fe(II):Fe(III) ratio, TPP:citrate ratio, and crosslinking time. The crystallite sizes of the Fe3O4 and chitosan- Fe3O4 nanoparticles was obtained from modified Debye Scherrer equation using data from XRD analysis. The crystallite size of the bare-Fe3O4 and chitosan-Fe3O4 nanoparticles were found to be about 6.22 and 9.49 nm, respectively. XRD analysis results shown that beside Fe3O4 phases there was γ-Fe2O3 phase due to the oxidation of Fe3O4.The crystallite sizes and the percentage of Fe3O4 decreases with increasing number of chitosan coating the Fe3O4 and the length of crosslinking time
Keywords
Full Text:
PDFReferences
Indira, T.K., and Lakshmi P.K. (2010), Magnetic Nanoparticles – A Review, International Journal of Pharmaceutical Sciences and Nanotechnology 3(3): 1035-1043.
Hou, Y., and Hao R. (2011), “Multifunctional Nanoparticles for Multimodal Molecular Imaging.” Nanoplatform-Based Molecular Imaging; Wiley: New Jersey, 571-572
Unsoy, G., Yalcin, S., Khodadust, R., Gunduz, F., and Gunduz, U., Synthesis optimization and characterization of chitosan- coated iron oxide nanoparticles produced for biomedical applications, J Nanopart Res. 14: 964-977
Wu, W., He, Q., and Jiang, C. (2008), Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies. Nanoscale Res Lett. 3: 397–415
Arami, H., Stephen, Z., Veiseh, O., and Zhang, M. (2011), Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery. Adv Polym Sci. 43: 163–184
Riva, R., Ragelle, H., Rieux, A., Duhem, N., Jerome, C., and Preat, V. (2011), Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering. Adv Polym Sci. 244: 19–44
Goulart, G.A.S., and Beppu, M.M. (2005), Preparation and characterization of chitosan microparticles modified with papain using crosslinking agents, XXI Congreso Interamericano and VIII Congreso Peruano de Ingenieia Quimica Lima, Peru 24 – 27 April 2005. Prosiding, 1-8
Liu, H., and Gao, C. (2009), Preparation and properties of ionically cross-linked chitosan nanoparticles, Polym. Adv. Technol. 20: 613–619
Shu, X.Z., and Zhu, K.J. (2002), Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure. International Journal of Pharmaceutics 233: 217– 225
Kavaz D., Sedat O., Eylem G., Murat D., and, Emir B. (2010), Bleomycin Loaded Magnetic Chitosan Nanoparticles as Multifunctional Nanocarriers, Journal of Bioactive and Compatible Polymers 25: 305-318
Monshi, A., Foroughi, M.R., and Monshi M.R. (2012), Modified Scherrer Eqquation to Estimate More Accurately Nano-Crystallite Size Using XRD, World Journal of Nano Science and Engineering 2: 154-160
Mahdavi,M., Mansor A., Md JelasH., Farideh N., Behzad N., Mohamad Z., and Jamileh A. (2013), Synthesis, surface modification and characterisation of biocompatible magnetic iron oxide nanoparticles for biomedical applications, Molecules 18: 7533-7548
Mi, Fwu-Long, Shin-Shing Shyu, Chin-Ta Chen, Juin-Yih Lai (2002), Adsorption of indomethacin onto chemically modified chitosan beads, Polimer 43: 757-765
Perlstein, B., Zvi, R., Dianne, D., Aharon, O., Yiftach, R., Shlomo, M., Yael, M. (2008), Convection-enhanced delivery of maghemite nanoparticles: Increased efficacy and MRI monitoring, Neuro Oncol. 10:153–16.
DOI: http://dx.doi.org/10.21776/ub.natural-b.2016.003.03.02
Refbacks
- There are currently no refbacks.